Novel Role of Silent Information Regulator 1 in Myocardial Ischemia
نویسندگان
چکیده
منابع مشابه
Novel role of silent information regulator 1 in myocardial ischemia.
Novel Role of Silent Information Regulator 1 in Myocardial Ischemia Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.113.00248
متن کاملSilent information regulator 1 protects the heart from ischemia/reperfusion.
BACKGROUND Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). METHODS AND RESULTS Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sirt1(-/-) mice exhibited a significant increase (44...
متن کامل[Neuroprotective role of silent information regulator 1 in Alzheimer's disease].
Silent information regulator 1 (SIRT1), an NAD(+)-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer's disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in A...
متن کاملSilent myocardial ischemia.
Silent myocardial ischemia is increasingly recognized as a common phenomenon in a variety of people with coronary artery disease. The natural history is poorly understood, but available data suggest that silent ischemia adversely affects prognosis in all groups studied. Based on this information, we believe that efforts should be directed at detecting and aggressively treating silent ischemic e...
متن کاملMolecular Cardiology Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion
Background—Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). Methods and Results—Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sirt1 Ϫ/Ϫ mice exhibited a significant increase (44Ϯ5%...
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ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.113.002480